CHARITIES and other non-government organisations could lose billions of dollars' worth of tax perks as the Rudd Government's taxation review prepares to examine whether the concessions offered to the $80 billion non-profit sector are justified.

The investigation, by Treasury boss Ken Henry, is expected to meet with resistance from some of the sector's most powerful groups, The Australian reports.

Most of the country's religious groups, which make up about $25 billion of the sector, run commercial enterprises.

Jim Wallace, Managing Director of Australian Christian Lobby, discusses the issue with David Gibbons from InFocus.